化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → Nirvanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1-Phenyl-1-propanone | HCID 7148 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | Ammonium Carbonate | HCID 517111 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Nirvanol | HCID 91480 | 66% |
反応手順
A solution of 26.8 g (0.2 mol) of propiophenone, 80 g (0.8 mol) of ammonium carbonate dissolved in 300 ml of water and 28 g (0.4 mol) of potassium cyanide in 300 ml of ethanol is heated under reflux for 8 hours, whilst stirring. The solution is cooled in a mixture of ice and salt; the hydantoin precipitates. The precipitate thus obtained is filtered off and washed with water. 27.1 g (yield: 66%) of 5-ethyl-5-phenyl-hydantoin, melting at 202° C., are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04225617 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-52f5033925664017858479f7330ce7e7 |
| 出典メモ | uspto-grants-1980_09 |