化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2-Hydroxy-3-nitro-5-trifluoromethylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-chloro-3-nitro-5-(trifluoromethyl)benzoic Acid | HCID 10084457 | — |
| 触媒 | Tetraethylammonium Chloride | HCID 5946 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Hydroxy-3-nitro-5-trifluoromethylbenzoic acid | HCID 23339952 | — |
反応手順
27 g of 2-chloro-3-nitro-5-trifluoromethyl-benzoic acid and 1 g of tetraethylammonium chloride are initially introduced into 200 ml of methanol, and 70 g of 50% strength sodium hydroxide solution are added dropwise, whilst stirring. The mixture is subsequently stirred at 65° C. for 5 hours, diluted with 300 ml of H2O and then rendered acid with hydrochloric acid. The solid product is filtered off and recrystallised from water. 16 g of 2-hydroxy-3-nitro-5-trifluoromethylbenzoic acid with the melting point: 166° to 168° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04225731 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-fd2f6a8cbede49f6b17762a83d57156c |
| 出典メモ | uspto-grants-1980_09 |