関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Chloro-5-nitrobenzotrifluoride | HCID 61213 | — |
| 触媒 | Tetraethylammonium Chloride | HCID 5946 | — |
| 生成物 | 4-Nitro-2-(trifluoromethyl)anisole | HCID 69562 | 60.7% |
反応手順
45 g of sodium hydroxide and 10 g of tetraethylammonium chloride in 200 g of methanol are initially introduced, 112.5 g of 2-chloro-5-nitro-benzotrifluoride are added dropwise at 25° to 30° C. and the mixture is then stirred at 30° C. for a further 5 hours. The mixture is then poured into 250 ml of water and extracted with methylene chloride. After evaporating off the solvent, the compound is recrystallised from isopropanol. 67 g of 2-methoxy-5-nitro-benzotrifluoride with a melting point of 70° to 74° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04225731 |
|---|
| 出典データセット | uspto-grants-1980_09 |
|---|
| ORD ID | ord-ce9d6417b525447fad8a7a50888eda11 |
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| 出典メモ | uspto-grants-1980_09 |
|---|
