1-Methylpyrrole → 1-(2,4-Dimethyl-5-thiazolyl)-1-(1-methyl-2-pyrrolyl)ethanol
反応式
C([Li])CCC.CN(CCN(C)C)C.[CH3:14][N:15]1[CH:19]=[CH:18][CH:17]=[CH:16]1.[C:20]([C:23]1[S:27][C:26]([CH3:28])=[N:25][C:24]=1[CH3:29])(=[O:22])[CH3:21]>C(OCC)C>[CH3:28][C:26]1[S:27][C:23]([C:20]([C:16]2[N:15]([CH3:14])[CH:19]=[CH:18][CH:17]=2)([OH:22])[CH3:21])=[C:24]([CH3:29])[N:25]=1参加物
6
実験手順
n-Butyllithium (2.5M solution in hexanes, 20 ml) in dry diethyl ether was cooled to -70° C. under dry nitrogen and TMEDA (5.8 g) was added. After 5 minutes, 1-methylpyrrole (5.4 g) in diethyl ether was added dropwise. After a further 15 minutes, 5-acetyl-2,4-dimethylthiazole (4.5 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and was then worked up in the usual fashion.
後処理
- waitAfter a further 15 minutes
- waitAfter 30 minutes the mixture was allowed
出典と根拠
- ORDレコード
- ord-a84f7dd10911495d860973d4009ad6f3
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731335
反応ノート
読み込み中…