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Hydroquinone → 4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroquinone | HCID 785 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(6-Chlorohexyloxy)tetrahydro-2H-pyran | HCID 329803 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol | HCID 17838576 | 82.5% |
反応手順
A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419620B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-7f83b244a5014c8fbe2f48fda79a83a5 |
| 出典メモ | uspto-grants-2008_09 |