4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyrimidin-2-amine → 1-[4-[[2-(2-Amino-4-methylpyrimidin-5-yl)-7-methyl-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

反応式

[CH3:30][c:31]1[n:32][c:33]([NH2:46])[n:34][cH:35][c:36]1[B:37]1[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]1.[Cl:1][c:2]1[n:3][c:4]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:23])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([C:18]([CH:19]([CH3:20])[OH:21])=[O:22])[CH2:16][CH2:17]1)[s:10]2>>[c:2]1(-[c:36]2[c:31]([CH3:30])[n:32][c:33]([NH2:46])[n:34][cH:35]2)[n:3][c:4]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:23])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([C:18]([CH:19]([CH3:20])[OH:21])=[O:22])[CH2:16][CH2:17]1)[s:10]2