Hydroxylamine → HCID 178476274、化合物

HRID 28377ノート

反応式

HRID 28377 の反応式
[C:1]([O:4][CH2:5][C:6]([C:13]#[N:14])([O:9][CH2:10][CH2:11][OH:12])[CH2:7][Cl:8])(=[O:3])[CH3:2].[NH2:15][OH:16]>C(O)C>[C:1]([O:4][CH2:5][C:6]([CH2:7][Cl:8])([O:9][CH2:10][CH2:11][OH:12])[C:13]([NH:15][OH:16])=[NH:14])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 787HydroxylamineHCID 574264383-Chloro-2-cyano-2-(2-hydroxyethoxy)propyl acetate

生成物 1

HCID 178476274HCID 178476274、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
65 °C

実験手順

A solution of 3-chloro-2-cyano-2-(2-hydroxyethoxy)propyl acetate (9.40 g, 42.4 mmol) in ethanol (150 mL) was treated with 50% aqueous hydroxylamine solution (2.94 g, 44.5 mmol, Aldrich) and the reaction was heated (65° C.) for 1.5 hrs. The solution was cooled to room temperature and the product was used as-is in the subsequent reaction: LC/MS m/z 255.20 (M+H).

後処理

  1. temperatureThe solution was cooled to room temperature
  2. customin the subsequent reaction

出典と根拠

ORDレコード
ord-d4f20087ccef4ab8adf0326ecde29be3
出典データセット
uspto-grants-2008_09
特許番号
US07419969B2

反応ノート

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