関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (2-Thienylmethyl)amine | HCID 34005 | — |
| 反応物 | 2-Amino-3-cyano4-chloroquinoline | HCID 11481121 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Amino-3-cyano-4-thenylaminoquinoline | HCID 22273720 | 49.4% |
反応手順
10 g of 2-amino-3-cyano-4-chloroquinoline is heated with 19 g of thienylmethylamine at 115° C. for 4 hours. The reaction mixture is cooled to 25° C. and mixed 6 times with 50 ml of water. The crystals are filtered off, washed 2 times with 50 ml of water and dried. The resulting product is recrystallized from 60 ml of N,N-dimethylformamide, to obtain 6.8 g pale yellow title compound, m.p.: 208-209° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07419977B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-5776aca0e38b491ba070be5d1aece8fa |
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| 出典メモ | uspto-grants-2008_09 |
|---|
