Benzenesulfonyl chloride → 4-Benzyloxy-3-(phenylsulphonylamino)phenyl acetate

HRID 28388ノート

反応式

HRID 28388 の反応式
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:7]([NH2:19])[CH:6]=1)(=[O:3])[CH3:2].C(N(CC)CC)C.[C:27]1([S:33](Cl)(=[O:35])=[O:34])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(Cl)Cl>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:7]([NH:19][S:33]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)(=[O:35])=[O:34])[CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 100153213-Amino-4-benzyloxyphenyl acetate

生成物 1

HCID 544537464-Benzyloxy-3-(phenylsulphonylamino)phenyl acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 5.0 g (0.0194 mol) of 4-benzyloxy-3-aminophenyl acetate, 3.3 ml (0.0236 mol) of triethylamine and 3.0 ml (0.0236 mol) of benzenesulphonyl chloride in 150 ml of methylene chloride is stirred at room temperature overnight. The mixture is then washed with water and the organic phase is dried, followed by purification by chromatography on a silica gel column, eluting with a 7/3 cyclohexane/ethyl acetate mixture. The compound of the title is obtained.

後処理

  1. washThe mixture is then washed with water
  2. customthe organic phase is dried
  3. customfollowed by purification by chromatography on a silica gel column
  4. washeluting with a 7/3 cyclohexane/ethyl acetate mixture
  5. customThe compound of the title is obtained

出典と根拠

ORDレコード
ord-40eb032d716e4c5bbe51acdd460f469d
出典データセット
uspto-grants-2008_09
特許番号
US07419974B2

反応ノート

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