関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | 2-Methoxy-4-nitrophenol | HCID 76738 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Methylenechloride Hexane | HCID 21226440 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Allyloxy-4-methoxynitrobenzene | HCID 12082202 | — |
反応手順
97.5 g (0.51 mole) of the sodium salt of 5-nitroguaiacol was dissolved in one liter of DMF and 1.5 equivalents of allyl bromide added. The reaction was heated to 65° C. for two hours, after which time much of the dark color had discharged and tlc (1:1 CH2Cl2/hexane) indicated loss of starting material. The solvent was concentrated in vacuum and the residue washed with water. The product was isolated by filtration and dried in a vacuum. This gave 112 g of pale yellow solid. A sample recrystallized from methanol, gave m.p. 93-94° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07419986B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-3f44aa63a8b8417582fb109a69f778d9 |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
