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Pyrrolidine → 1-(1,3-Dioxobutyl)pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | Diketene acetone | HCID 87118046 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(1,3-Dioxobutyl)pyrrolidine | HCID 100722 | 97.9% |
反応手順
9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731322 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-fc50405695d1443a80eda06a3dd99d45 |
| 出典メモ | uspto-grants-1998_03 |