Methanol → Methyl (2-chlorophenyl)acetate
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]参加物
4
実験手順
To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5%) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).
後処理
- temperaturethe solution was refluxed for 16 hours
- concentrationAfter concentration
- washwashed with sat'd aq. NaHCO3, H2O and brine
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-03a2d924d59c4293b06e1c1ba8bab7f0
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419983B2
反応ノート
読み込み中…