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3-Hydroxybenzaldehyde → 2-Chloro-3-hydroxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxybenzaldehyde | HCID 101 | — |
| 反応物 | Tert-Butyl hypochlorite | HCID 521297 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Chloro-3-hydroxybenzaldehyde | HCID 593376 | 55% |
反応手順
To a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL) was added carefully tBuOCl (20 mL, 176 mmol) with stirring. The reaction became a clear solution and strongly exothermic. It was allowed to cool and stirred for 16 hours, resulting in a white precipitate. The solid was filtered, washed with H2O and dried to give 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55%), GCMS (EI) m/z 156, 158 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419983B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-1a18f9f73569446985b955cf53886dc5 |
| 出典メモ | uspto-grants-2008_09 |