化工社化工社 化学情報印刷レポート · 研究参考用
Acetonedicarboxylic acid → 8-Benzyl-8-azabicyclo(3.2.1)octan-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonedicarboxylic acid | HCID 68328 | — |
| 反応物 | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| 反応物 | Amino tropane | HCID 67082042 | — |
| 生成物 | 8-Benzyl-8-azabicyclo(3.2.1)octan-3-one | HCID 119846 | — |
反応手順
For example, the protected aminotropane intermediate 16 can be prepared by reacting 2,5-dimethoxy tetrahydrofuran 17 with 1,3-acetonedicarboxylic acid 18 to provide 8-benzyl-8-azabicyclo[3.2.1]octan-3-one 19, commonly N-benzyltropanone. N-benzyltropanone is then reacted with a slight excess of di-tert-butyl dicarbonate in the presence of a transition metal catalyst to provide the protected Boc intermediate 20, which is reduced to provide the protected aminotropane intermediate 16.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419989B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-dd6f8a06142f4aa1b15ab253a9404259 |
| 出典メモ | uspto-grants-2008_09 |