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p-Toluidine → 6-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluidine | HCID 7813 | — |
| 反応物 | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine | HCID 238748 | 60% |
反応手順
A mixture of 4,6-dichloro-pyrimidin-2-yl-amine (3.3 g, 20 mmol), p-tolylamine (3.4 g, 32 mmol) and N,N-diisopropylethylamine (12 ml) in ethanol (150 ml) was heated under reflux for 40 hours. After cooling to room temperature, filtration provided 6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine (2.8 g, 60% yield) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-4b58f671d02747c482395d81bde4e44d |
| 出典メモ | uspto-grants-2008_09 |