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Ethyl 3-(5-chloro-2-methylphenyl)-3-oxopropanoate → Acetamidine monohydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 3-(5-chloro-2-methylphenyl)-3-oxopropanoate | HCID 58063452 | — |
| 反応物 | 4-Chloro-6-(5-chloro-2-methoxyphenyl)-2-methylpyrimidine | HCID 65645326 | — |
| 生成物 | Acetamidine monohydrochloride | HCID 67170 | 11% |
| 生成物 | 4-Chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine | HCID 86004323 | — |
反応手順
4-Chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine was prepared according to the method described in Example 38 for the synthesis of 4-chloro-6-(5-chloro-2-methoxy-phenyl)-2-methyl-pyrimidine in two steps using 3-(5-chloro-2-methyl-phenyl)-3-oxopropionic acid ethyl ester and acetamidine hydrochloride (11% yield). 1H NMR (DMSO-d6) δ 2.36 (s, 3H, CH3), 2.68 (s, 3H, CH3), 7.40 (d, 1H, J=8.3 Hz, Ar), 7.49 (dd, 1H, J=8.3 Hz, J=2.3 Hz, Ar), 7.57 (d, 1H, J=2.3 Hz, Ar), 7.79 (s, 1H, Ar).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-bae5914d1f5341669c054fa5645d9205 |
| 出典メモ | uspto-grants-2008_09 |