反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH2:9])[N:3]=1.C([O-])(=O)C.[Na+].[Br:15]Br>C(O)(=O)C>[NH2:9][C:4]1[N:5]=[C:6]([Cl:8])[C:7]([Br:15])=[C:2]([Cl:1])[N:3]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a stirred mixture of 4,6-dichloro-pyrimidin-2-yl-amine (2.46 g, 15.0 mmol) and sodium acetate (6.15 g, 75.0 mmol) in acetic acid (150 ml) was added bromine (3.24 g, 20.25 mmol) dropwise. The mixture was then stirred at 60° C. for 2 hours. Volatiles were evaporated under reduced pressure. The residue was stirred with water (500 ml) for 1 hour, filtered, and dried under reduced pressure to provide 2-amino-4,6-dichloro-5-bromo-pyrimidine (3.2 g, 88% yield) as a white solid.
後処理
- customVolatiles were evaporated under reduced pressure
- stirringThe residue was stirred with water (500 ml) for 1 hour
- filtrationfiltered
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-16b556802db94a128af4492aaa101a92
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419984B2
関連ノート
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