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1H-Indazol-6-amine → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(1H-indazol-6-yl)-pyrimdine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-Indazol-6-amine | HCID 81423 | — |
| 反応物 | 4-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine | HCID 86004325 | — |
| 生成物 | 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(1H-indazol-6-yl)-pyrimdine-2,4-diamine | HCID 11361007 | 65% |
反応手順
Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 1H-indazol-6-ylamine provided the title compound (65% yield). 1H NMR (DMSO-d6) δ 1.34 (t, 3H, J=6.9 Hz, CH3), 4.13 (q, 2H, J=6.9 Hz, CH2), 6.26 (s, 2H, NH2), 6.85 (s, 1H, Ar), 7.14 (d, 1H, J=8.9 Hz, Ar), 7.30 (d, 1H, J=8.6 Hz, Ar), 7.41 (dd, 1H, J-8.9 Hz, 2.7 Hz, Ar), 7.65 (d, 1H, J=8.9 Hz, Ar), 7.95-7.97 (m, 3H, Ar), 9.27 (s, 1H, NH), 12.80 (s, 1H, NH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-d04a9222be6f44e9b70be08468a6ca07 |
| 出典メモ | uspto-grants-2008_09 |