4-(Trifluoromethyl)aniline → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine

関与物質

反応手順

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-trifluoromethyl-phenylamine provided the title compound (78% yield). 1H NMR (DMSO-d6) δ 1.40 (t, 3H, J=6.9 Hz, CH3), 4.15 (q, 2H, J=6.9 Hz, CH2), 6.45 (s, 2H, NH2), 6.84 (s, 1H, Ar), 7.16 (d, 1H, J=8.9 Hz, Ar), 7.43 (dd, 1H, J=8.8 Hz, 2.8 Hz, Ar), 7.61 (d, 2H, J=8.9 Hz, Ar), 7.93 (d, 1H, J=2.8 Hz, Ar), 7.99 (d, 2H, J=8.9 Hz), 9.59 (s, 1H, NH).

情報源と証拠