P-Anisidine → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-methoxy-phenyl)-pyrimidine-2,4-diamine

HRID 28575

反応式

HRID 28575 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:16][CH3:17])[N:5]=[C:4]([NH2:18])[N:3]=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=1>>[Cl:14][C:12]1[CH:11]=[CH:10][C:9]([O:15][CH2:16][CH3:17])=[C:8]([C:6]2[N:5]=[C:4]([NH2:18])[N:3]=[C:2]([NH:27][C:24]3[CH:25]=[CH:26][C:21]([O:20][CH3:19])=[CH:22][CH:23]=3)[CH:7]=2)[CH:13]=1

参加物

3

反応物 2

HCID 7732P-AnisidineHCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

生成物 1

HCID 113721566-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-methoxy-phenyl)-pyrimidine-2,4-diamine収率 61%

実験手順

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-methoxy-phenylamine provided the title compound (61% yield). 1H NMR (DMSO-d6) δ 1.34 (t, 3H, J=6.9 Hz, CH3), 3.74 (s, 3H, CH3), 4.10 (q, 2H, J=7.0 Hz, CH2), 6.18 (s, 2H, NH2), 6.71 (s, 1H, Ar), 6.89 (d, 2H, J=8.6 Hz, Ar), 7.12 (d, 1H, J=8.9 Hz, Ar), 7.39 (dd, 1H, J=8.8 Hz, 2.9 Hz, Ar), 7.53 (d, 2H, J=8.6 Hz, Ar), 7.94 (d, 1H, J=2.8 Hz, Ar), 8.93 (s, 1H, NH).

出典と根拠

ORDレコード
ord-29ed1b24e7cc4ae08ed130bef687e9f1
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

関連ノート

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