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HRID 28589作成日：2026年10月26日

4-Aminophenethyl alcohol → 2-{4-[2-Amino-6-(2,5-dimethyl-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanol

https://huagongshe.com/reaction/28589

反応式

関与物質

役割名称HCID仕込み量
反応物4-Aminophenethyl alcoholHCID 66904—
反応物4-Chloro-6-(2,5-dimethyl-phenyl)-pyrimidin-2-yl-amineHCID 86594602—
生成物2-{4-[2-Amino-6-(2,5-dimethyl-phenyl)-pyrimidin-4-ylamino]-phenyl}-ethanolHCID 11256113—

反応手順

Following the method described in Example 4, 4-chloro-6-(2,5-dimethyl-phenyl)-pyrimidin-2-yl-amine and 4-aminophenethyl alcohol provided the title compound as hydrochloride salt (85% yield). 1H NMR (DMSO-d6) δ 2.29 (s, 6H, CH3), 6.30 (s, 1H, Ar), 7.24-7.31 (m, 5H, Ar), 7.68 (d, 2H, J=8.0 Hz, Ar), 10.67 (s, 1H), 12.54 (s, 1H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07419984B2
出典データセットuspto-grants-2008_09
ORD IDord-1ae65515b940409bbc78a6d91052e995
出典メモuspto-grants-2008_09