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4-Nitroaniline → 6-(5-Bromo-2-methyl-phenyl)-N*4*-(4-nitro-phenyl)-pyrimidine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitroaniline | HCID 7475 | — |
| 反応物 | 2-Amino-4-chloro-6-(2-methyl-5-bromo-phenyl)-pyrimidine | HCID 86004341 | — |
| 生成物 | 6-(5-Bromo-2-methyl-phenyl)-N*4*-(4-nitro-phenyl)-pyrimidine-2,4-diamine | HCID 11384005 | 74% |
反応手順
Following the method described in Example 26, 4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine and 4-nitro-phenylamine provided the title compound (74% yield). 1H NMR (CD3OD) δ 2.41 (s, 3H, CH3), 6.42 (s, 1H, Ar), 7.39 (d, 1H, J=8.0 Hz, Ar), 7.67-7.70 (m, 2H, Ar), 8.14 (d, 2H, J=9.0 Hz, Ar), 8.31-8.34 (m, 2H, Ar).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-47733bb9bdf34592b169a13dab6e89bd |
| 出典メモ | uspto-grants-2008_09 |