2,2,2-Trifluoroethyl trifluoromethanesulfonate → 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene

HRID 28609

反応式

HRID 28609 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.BrC1C=C(Cl)C=CC=1O[CH2:18][C:19]([F:22])([F:21])[F:20].FC(F)(F)COS(C(F)(F)F)(=O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 865946032-Bromo-4-chloro-1-(2,2,2-trifluoro-ethoxy)-benzene 4-bromo-phenol

生成物 1

HCID 229138831-Bromo-4-(2,2,2-trifluoroethoxy)benzene収率 40%

実験手順

Following the method described in Example 89 for the synthesis of 2-bromo-4-chloro-1-(2,2,2-trifluoro-ethoxy)-benzene 4-bromo-phenol and trifluoro-methanesulfonic acid 2,2,2-trifluoro-ethyl ester gave 1-bromo-4-(2,2,2-trifluoro-ethoxy)-benzene (40% yield). 1H NMR (acetone-d6) δ 4.68 (q, 2H, J=8.5 Hz, CH2), 7.04 (d, 2H, J=9.1 Hz, Ar), 7.49 (d, 2H, J=9.1 Hz, Ar).

出典と根拠

ORDレコード
ord-c912224cf53a4801a4416a5bc234448f
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

関連ノート

読み込み中…