3-(4-Aminophenyl)propionic acid → 4-Aminobenzenepropanol

HRID 28611

反応式

HRID 28611 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 754513-(4-Aminophenyl)propionic acidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 2204244-Aminobenzenepropanol収率 89%

実験手順

To a mixture of 3-(4-amino-phenyl)-propionic acid (1.85 g, 11.2 mmol) and tetrahydrofuran′(200 ml), was added lithium aluminum hydride (1.0 g, 26 mmol). After stirring for 3 hours, the mixture was quenched by addition of methanol (5 ml) and concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (100 ml) and extracted with ethyl acetate (200 ml). The organic extract was concentrated under reduced pressure to give 3-(4-amino-phenyl)-propan-1-ol (1.5 g, 89% yield).

後処理

  1. customthe mixture was quenched by addition of methanol (5 ml)
  2. concentrationconcentrated under reduced pressure
  3. additionThe residue was treated with saturated aqueous sodium chloride solution (100 ml)
  4. extractionextracted with ethyl acetate (200 ml)
  5. extractionThe organic extract
  6. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2d30637f3a09471486294a64214e35e3
出典データセット
uspto-grants-2008_09
特許番号
US07419984B2

関連ノート

読み込み中…