3-(4-Aminophenyl)propionic acid → 4-Aminobenzenepropanol
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:7]=1参加物
3
実験手順
To a mixture of 3-(4-amino-phenyl)-propionic acid (1.85 g, 11.2 mmol) and tetrahydrofuran′(200 ml), was added lithium aluminum hydride (1.0 g, 26 mmol). After stirring for 3 hours, the mixture was quenched by addition of methanol (5 ml) and concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (100 ml) and extracted with ethyl acetate (200 ml). The organic extract was concentrated under reduced pressure to give 3-(4-amino-phenyl)-propan-1-ol (1.5 g, 89% yield).
後処理
- customthe mixture was quenched by addition of methanol (5 ml)
- concentrationconcentrated under reduced pressure
- additionThe residue was treated with saturated aqueous sodium chloride solution (100 ml)
- extractionextracted with ethyl acetate (200 ml)
- extractionThe organic extract
- concentrationwas concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-2d30637f3a09471486294a64214e35e3
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07419984B2
反応ノート
読み込み中…