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2-Chloroaniline → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(2-chloro-phenyl)-pyrimidine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloroaniline | HCID 7240 | — |
| 反応物 | 4-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine | HCID 86004325 | — |
| 生成物 | 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(2-chloro-phenyl)-pyrimidine-2,4-diamine | HCID 44314131 | 31% |
反応手順
Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 2-chloroaniline provided the title compound (31% yield). 1H NMR (DMSO-d6) δ 1.19-1.22 (t, 3H, CH3), 4.0-4.1 (q, 2H, CH2), 6.0-6.30 (s, 2H, NH2), 6.65 (s, 1H, Ar), 7.05-7.29 (m, 4H, Ar), 7.316 (d, 1H, Ar) 7.354 (d, 1H, Ar) 7.90 (d, 1H, Ar) 8.8 (br s, 1H, NH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-473731f08edb4fc6bd00d07111c1c57f |
| 出典メモ | uspto-grants-2008_09 |