1-Hexanol → 4-(5-Bromo-2-hexyloxy-phenyl)-6-chloro-pyrimidin-2-ylamine

反応式

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18][CH3:19])=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1.NC1N=[C:25](C2C=C(Br)C=CC=2O)[CH:24]=[C:23](Cl)N=1.C(O)CCCCC>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH2:18][CH2:19][CH2:23][CH2:24][CH3:25])=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1

参加物

反応物 3

HCID 81031-Hexanol

HCID 860043744-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

HCID 1360800122-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

生成物 1

HCID 860043814-(5-Bromo-2-hexyloxy-phenyl)-6-chloro-pyrimidin-2-ylamine収率 47%

実験手順

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and hexan-1-ol provided 4-(5-bromo-2-hexyloxy-phenyl)-6-chloro-pyrimidin-2-ylamine (47% yield).

出典と根拠

ORDレコード: ord-fdf4ee5e892f4551afb69f72041b8fa0
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07419984B2

反応ノート

読み込み中…

参加物