化工社化工社 化学情報印刷レポート · 研究参考用
p-Toluidine → 6-[5-Bromo-2-(2-methoxy-benzyloxy)-phenyl]-N*4*-p-tolyl-pyrimidine-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluidine | HCID 7813 | — |
| 反応物 | HCID 178489517 | HCID 178489517 | — |
| 生成物 | 6-[5-Bromo-2-(2-methoxy-benzyloxy)-phenyl]-N*4*-p-tolyl-pyrimidine-2,4-diamine | HCID 42606990 | 36% |
反応手順
Following the method described in Example 4, 6-[5-bromo-2-(2-methoxy-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine and 4-methyl-phenylamine provided the title compound (36% yield). 1H NMR (CD3OD) δ 3.82 (s, 3H, CH3), 5.25 (s, 2H, CH2), 6.32 (s, 1H, Ar), 6.89-6.98 (m, 2H, Ar), 7.21-7.30 (m, 6H, Ar), 7.59-7.72 (m, 3H, Ar).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-f7275f0f88e743ceab141c46b63b009a |
| 出典メモ | uspto-grants-2008_09 |