[CH:1]([N:4]([CH:31]([CH3:33])[CH3:32])[C:5]([C:7]1[NH:29][C:10]2[CH2:11][C@@:12]3([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([O:27]C)[CH:22]=4)[C@H:17]([CH2:18][C:9]=2[C:8]=1[CH3:30])[CH2:16][N:15]([CH2:19][CH3:20])[CH2:14][CH2:13]3)=[O:6])([CH3:3])[CH3:2].B(Br)(Br)Br.[ClH:38].CCOCC>CO>[ClH:38].[CH:31]([N:4]([CH:1]([CH3:2])[CH3:3])[C:5]([C:7]1[NH:29][C:10]2[CH2:11][C@@:12]3([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([OH:27])[CH:22]=4)[C@H:17]([CH2:18][C:9]=2[C:8]=1[CH3:30])[CH2:16][N:15]([CH2:19][CH3:20])[CH2:14][CH2:13]3)=[O:6])([CH3:33])[CH3:32]1.0 g (2.2 mmol) of (±)-trans-2-diisopropylaminocarbonyl-6-ethyl-8a-(3-methoxyphenyl)-3-methyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g] isoquinoline were treated with 1.15 ml (12.0 mmol) of boron tribromide as described in example 2. The crude product was dissolved in MeOH and the solution brought to acidic pH with HCl/Et2O . The solvent was evaporated in vacuo and the solid crystallized from acetone, yielding 0.5 g of the title compound. M.p.=263°-265° C.
読み込み中…