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Hydrochloric Acid → 3-chlorophenyl-2-[4-(2-phenylpropyl)piperazin-1-yl]ethylcyclohexanol Dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Phenylpropanal | HCID 7146 | — |
| 反応物 | 1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol | HCID 10381502 | — |
| 反応物 | 1-{1-(3-Chlorophenyl)-2-[4-(2-phenylpropyl)piperazin-1-yl]ethyl}cyclohexanol dihydrochloride | HCID 11249288 | — |
| 生成物 | 3-chlorophenyl-2-[4-(2-phenylpropyl)piperazin-1-yl]ethylcyclohexanol Dihydrochloride | HCID 86600406 | — |
反応手順
In an analogous manner to Example 117, 1-{1-(3-chlorophenyl)-2-[4-(2-phenylpropyl)piperazin-1-yl]ethyl}cyclohexanol dihydrochloride was prepared from 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 1) and 2-phenylpropionaldehyde. MS (ESI) m/z 441/443 ([M+H]+); HRMS: calcd for C27H37ClN2O.2.00 HCl, 512.2128; found (ESI), 441.2662.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419980B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-4df71547f8b34476aa219a6c6686f85e |
| 出典メモ | uspto-grants-2008_09 |