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Potassium Cyanide → 4-(7-Methoxy-1-naphthyl)butyronitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 3-(7-Methoxy-1-naphthyl)propyl mesylate | HCID 15336867 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 4-(7-Methoxy-1-naphthyl)butyronitrile | HCID 15336868 | — |
反応手順
In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731352 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-ebf01e6b38bc42c089b9940d05b2423f |
| 出典メモ | uspto-grants-1998_03 |