反応式
[NH2:1][C:2]([NH2:19])=[N:3][C:4](=[O:18])[C:5]1[CH:10]=[C:9]([S:11]([CH3:14])(=[O:13])=[O:12])[C:8]([C:15]#[CH:16])=[CH:7][C:6]=1[CH3:17].CC1C=C(Br)C(S(C)(=O)=O)=CC=1C(OC)=O.CC1C=C(C#C)C(S(C)(=O)=O)=CC=1C(OC)=O.NC(N)=N.[H][H]>CN(C=O)C.[Pd].C([O-])([O-])=O.[Ca+2]>[NH2:19][C:2]([NH2:1])=[N:3][C:4](=[O:18])[C:5]1[CH:10]=[C:9]([S:11]([CH3:14])(=[O:12])=[O:13])[C:8]([CH:15]=[CH2:16])=[CH:7][C:6]=1[CH3:17]参加物
8
反応物 5
生成物 1
試薬・触媒・溶媒 2
実験手順
6.0 g of N-diaminomethylene-2-methyl-4-ethynyl-5-methylsulfonylbenzamide, m.p. 223°-226° [obtainable by reaction of methyl 2-methyl-4-bromo-5-methylsulfonyl-benzoate with Li acetylide to give methyl 2-methyl-4-ethynyl-5-methylsulfonyl-benzoate and subsequent reaction with guanidine] are dissolved in 300 ml of DMF and hydrogenated in the presence of 450 mg of Pd-CaCO3 (Lindlar catalyst) for 15 minutes in a stream of hydrogen (p=1 bar). Customary working up gives N-diaminomethylene-2-methyl-4-ethenyl-5-methylsulfonyl-benzamide).
出典と根拠
- ORDレコード
- ord-b9a7eb44685f468d8f6ff10d7448f0ce
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05731351
関連ノート
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