Water → 1-(2-Isothiocyanatoethyl)-2-methoxybenzene

HRID 29026

反応式

HRID 29026 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][CH2:6][NH2:7].[C:12](Cl)(Cl)=[S:13].O>C(OCC)C>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][CH2:6][N:7]=[C:12]=[S:13]

参加物

5

反応物 3

HCID 962WaterHCID 10040ThiophosgeneHCID 748962-Methoxyphenethylamine

生成物 1

HCID 121467891-(2-Isothiocyanatoethyl)-2-methoxybenzene収率 71.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 2-methoxyphenethylamine (1.98 g) in diethylether (20 ml) was added dropwise under ice-cooling thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the solution was added water (30 ml). The mixture was extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxyphenethyl)isothiocyanate (1.80 g, yield: 71%) as brown oil.

後処理

  1. extractionThe mixture was extracted with diethylether (60 ml)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ddede0c2054249e582b880823d590b78
出典データセット
uspto-grants-2008_09
特許番号
US07420053B2

関連ノート

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