化工社化工社 化学情報印刷レポート · 研究参考用
Phloroglucinol → 5,7-Dihydroxy-4-methylcoumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phloroglucinol | HCID 359 | — |
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Sulfuric acid hydrate (1:1) | HCID 21910475 | — |
| 生成物 | 5,7-Dihydroxy-4-methylcoumarin | HCID 5354284 | — |
反応手順
A mixture of 2.77 g (22 mmol) of phloroglucinol and 2.6 g (20 mmol) of ethyl acetoacetate were melted together, the mixture was cooled, and 40 ml of a mixture of sulfuric acid/water (75% w/w) was added rapidly to the semi-solid mass. The mixture was stirred for 24 h, during which time a semi-solid mass formed. It was poured into a mixture of ice/water (300 ml) containing 5 g of sodium acetate and the precipitate was recovered by suction filtration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07420054B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-633683c5b109479a96268fd5d4c3e362 |
| 出典メモ | uspto-grants-2008_09 |