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4-Benzyloxy-6-[2-(3,4-dibenzyloxyphenyl)-2-hydroxyethyl]-2H-pyran-2-one → 4-Hydroxy-6-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-2H-pyran-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Benzyloxy-6-[2-(3,4-dibenzyloxyphenyl)-2-hydroxyethyl]-2H-pyran-2-one | HCID 19688074 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Hydroxy-6-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-2H-pyran-2-one | HCID 86752320 | 70% |
反応手順
35.6 g (66.6 mmol) 4-benzyloxy-6-[2-[3,4-dibenzyloxyphenyl)-2-hydroxy-ethyl)]-2H-pyran-2-one (VI) was hydrogenated for 6 hours at room temperature under a hydrogen pressure of 44 mbar in 1200 ml ethanol using 10 g W2 Raney nickel. After taking up 4.4 l hydrogen the catalyst was removed by suction filtration and it was rewashed several times with tetrahydrofuran. The evaporated filtrates yielded 12.2 g (70%) VII after triturating with ether, melting point 153° C. (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731344 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-65ca9c80774841d78cc6437f7406abeb |
| 出典メモ | uspto-grants-1998_03 |