関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 4-Hydroxymethyl-3-methylbenzofuran-2-carboxylic acid ethyl ester | HCID 68711892 | — |
| 触媒 | Silver(II) oxide | HCID 92152 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Ethyl 4-(methoxymethyl)-3-methyl-1-benzofuran-2-carboxylate | HCID 68715936 | 93.8% |
反応手順
To a solution of 0.19 g (0.81 mmole) of ethyl 4-(hydroxymethyl)-3-methyl-1-benzofuran-2-carboxylate (Example 92, Step 2) in 2 mL of chloroform was added silver (II) oxide (0.34 g, 1.46 mmol, 1.8 eq) and 2 mL of iodomethane and the mixture was heated in sealed tube at ˜55° C. for 4.5 days. The reaction was filtered and concentrated in vacuo to provide 0.20 g of ethyl 4-(methoxymethyl)-3-methyl-1-benzofuran-2-carboxylate. Yield: ˜93.8% m.p. 45-47° C.; MS: 249.1(M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07420001B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-faa43fcc2f5947b3afc920a756a3a1bb |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
