2-Bromopropane → HCID 68716041、化合物

HRID 29338ノート

反応式

HRID 29338 の反応式
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[C:8]=2[CH:9]=1)=[O:4].Br[CH:16]([CH3:18])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:16]([O:14][C:10]1[C:8]2[CH:9]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[O:6][C:7]=2[CH:13]=[CH:12][CH:11]=1)([CH3:18])[CH3:17]

参加物

5

反応物 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 14494065Methyl 4-hydroxybenzofuran-2-carboxylate

生成物 1

HCID 68716041HCID 68716041、化合物収率 100%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 0.41 g (2.13 mmol) of 4-hydroxy-2-benzofurancarboxylic acid methyl ester in 7 mL of DMF was added 0.80 mL (8.54 mmol) of 2-bromopropane and 1.18 g (8.54 mmol) of potassium carbonate. The reaction was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo, and the residue was extracted with ethyl acetate. The organic layer washed with water and brine, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 0.49 g of methyl 4-isopropoxy-1-benzofuran-2-carboxylate. Yield ˜100%; m.p. 43-45° C.; MS: 235.1 (M+H)+.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe organic layer washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-15c5f1d5dfe849a5a6c5355f7b711ebf
出典データセット
uspto-grants-2008_09
特許番号
US07420001B2

反応ノート

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