2-Amino-m-cresol → HCID 68715276、化合物

HRID 29436

反応式

HRID 29436 の反応式
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([O:12][C:13](OCC)([O:19]CC)[C:14](OCC)=O)[CH3:11]>>[CH2:10]([O:12][C:13]([C:14]1[O:9][C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=2[N:1]=1)=[O:19])[CH3:11]

参加物

3

反応物 2

HCID 30141382-Amino-m-cresolHCID 5090273Ethyl 2,2,2-triethoxyacetate

生成物 1

HCID 68715276HCID 68715276、化合物収率 81.8%

反応条件

温度
110 °C

実験手順

To 2-amino-3-methylphenol (1 g, 8.1 mmol) was added ethyl triethoxyacetate (5.4 g, 3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 1.36 g of 4-methyl-benzooxazole-2-carboxylic acid ethyl ester as a white solid.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customtriturated with hexane
  3. filtrationFiltration

出典と根拠

ORDレコード
ord-d18a99cea9294eaf86b4b5e9b54c5e24
出典データセット
uspto-grants-2008_09
特許番号
US07420001B2

関連ノート

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