関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-4-methylphenol | HCID 7264 | — |
| 反応物 | Ethyl 2,2,2-triethoxyacetate | HCID 5090273 | — |
| 生成物 | 5-Methyl-benzooxazole-2-carboxylic acid ethyl ester | HCID 68713060 | 91% |
反応手順
To 2-amino-4-methylphenol (1 g, 8.1 mmol) was added ethyl triethoxyacetate (5.4 g, 3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 850 mg (91%) of 5-methyl-benzooxazole-2-carboxylic acid ethyl ester as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07420001B2 |
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| 出典データセット | uspto-grants-2008_09 |
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| ORD ID | ord-8b7b0d44b47645e18d89b4e26aef221a |
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| 出典メモ | uspto-grants-2008_09 |
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