関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-4-(trifluoromethyl)benzenethiol | HCID 88042 | — |
| 反応物 | Ethyl 2,2,2-triethoxyacetate | HCID 5090273 | — |
| 生成物 | Ethyl 5-(trifluoromethyl)-2-benzothiazolecarboxylate | HCID 55189808 | — |
反応手順
To 2-amino-4-trifluoromethyl-benzenethiol (0.7 g) was added ethyl triethoxyacetate (3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 460 mg of 5-trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07420001B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-0b562ebc862241489a596e1f9fcc353b |
|---|
| 出典メモ | uspto-grants-2008_09 |
|---|
