1,1'-Binaphthyl → N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-(cis-2,6-dimethyl-morpholin-4-yl)-benzenesulfonamide

関与物質

役割	名称	HCID	仕込み量
反応物	1,1'-Binaphthyl	HCID 11789	—
反応物	2,6-Dimethylmorpholine, cis-	HCID 641500	—
反応物	4-Bromo-N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide	HCID 10072530	—
反応物	Potassium phosphate, tribasic, monohydrate	HCID 22031701	—
触媒	Palladium	HCID 23938	—
溶媒	1,4-Dioxane	HCID 31275	—
生成物	N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-(cis-2,6-dimethyl-morpholin-4-yl)-benzenesulfonamide	HCID 59788547	—

反応手順

The title compound was prepared according to the general procedure for the synthesis of heterocyclyl and heteroaryl substituted phenylsulfonyl derivatives previously described, using 4-Bromo-N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide 0.3 g (0.66 mmol), potassium phosphate tribasic monohydrate 0.91 g (3.96 mmol), rac-2,2′-bis diphenylphosphino)-1,1′-binaphthyl 0.12 g (0.198 mmol), cis-2,6-dimethylmorpholine 0.37 g (3.3 mmol) and Pd (dba)3 60 mg (0.066 mmol) in 6 ml dioxane, followed by work up and HPLC purification: LC-MSD, m/z for C24H24ClN3O4S [M+H]+: 486.0

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07420055B2
出典データセット	uspto-grants-2008_09
ORD ID	ord-2d3835e24ca0434a96109c9e18f361e6
出典メモ	uspto-grants-2008_09