Thiomorpholine → N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-thiomorpholin-4-yl-benzenesulfonamide

関与物質

役割	名称	HCID	仕込み量
反応物	Thiomorpholine	HCID 67164	—
反応物	Binap, (A+-)-	HCID 634876	—
反応物	4-Bromo-N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide	HCID 10072530	—
反応物	Potassium phosphate, tribasic, monohydrate	HCID 22031701	—
触媒	Palladium	HCID 23938	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-thiomorpholin-4-yl-benzenesulfonamide	HCID 59788694	—

反応手順

The title compound was prepared according to the general procedure for the synthesis of heterocyclyl and heteroaryl substituted phenylsulfonyl derivatives previously described, using 4-Bromo-N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-benzenesulfonamide 0.3 g (0.66 mmol), potassium phosphate tribasic monohydrate 0.91 g (3.96 mmol), rac-2,2′-bis (diphenylphosphino)-1,1′-binaphthyl 0.12 g (0.198 mmol), thiomorpholine 0.34 g (3.3 mmol) and Pd (dba)3 60 mg (0.066 mmol) in 3 ml DMF followed by work up and HPLC purification: LC-MSD, m/z for C22H20ClN3O3S2 [M+H]+: 474.0

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07420055B2
出典データセット	uspto-grants-2008_09
ORD ID	ord-ae7340eb56cc411c847d695c2bfab5f2
出典メモ	uspto-grants-2008_09