4-(1,3-Oxazol-5-yl)benzenesulphonyl chloride → N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-oxazol-5-yl-benzenesulfonamide

HRID 29548

反応式

HRID 29548 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)=[O:10].[O:17]1[C:21]([C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)=[CH:20][N:19]=[CH:18]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][S:28]([C:25]2[CH:26]=[CH:27][C:22]([C:21]3[O:17][CH:18]=[N:19][CH:20]=3)=[CH:23][CH:24]=2)(=[O:29])=[O:30])=[C:3]([C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:10])[CH:4]=1

参加物

3

反応物 2

HCID 27764154-(1,3-Oxazol-5-yl)benzenesulphonyl chlorideHCID 10214538(2-Amino-5-chlorophenyl)-pyridin-4-yl methanone

生成物 1

HCID 10003340N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-oxazol-5-yl-benzenesulfonamide

実験手順

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 122 mg 4-oxazol-5-yl-benzenesulfonyl chloride. Purification by purification by reversed phase HPLC gave pure product. 1H-NMR (400 MHz, CDCl3): δ 7.21 (dd, H, J=1.5, 4.4 Hz), 7.30 (d,1H, J=2.5 Hz), 7.42 (s,1H), 7.54 (dd,1H, J=2.5, 8.8 Hz 7.61 (d, 2H, J=8.4 Hz), 7.77 (s,1H), 7.78 (d, 2H, J=8.4 Hz), 7.95 (s,1H), 8.69 (d, 2H, J=5.8 Hz), 10.06 (br, 1H). MS: m/z 440.9 (M++1).

後処理

  1. customPurification
  2. customby purification by reversed phase HPLC
  3. customgave pure product

出典と根拠

ORDレコード
ord-de209a10242b432e91716e662611bba2
出典データセット
uspto-grants-2008_09
特許番号
US07420055B2

関連ノート

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