4-(1,3-Oxazol-5-yl)benzenesulphonyl chloride → N-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)phenyl]-4-oxazol-5-yl-benzenesulfonamide

関与物質

反応手順

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 123 mg of (2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone and 122 mg of 4-oxazol-5-yl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 2.78 (s, 3H), 7.29 (d,1H, J=2.8 Hz), 7.45 (m, 2H), 7.48 (s,1H), 7.55 (dd,1H, J=9.2 Hz, 2.8 Hz)), 7.67 (m, 3H), 7.83 (d, 2H, J=8.4 Hz), 8.03 (s,1H), 8.81 (d, 1H, J=5.6 Hz), 10.10 (s, 1H). MS: m/z454.9 (M++1).

情報源と証拠