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p-(Trifluoromethoxy)benzenesulphonyl chloride → N-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-(Trifluoromethoxy)benzenesulphonyl chloride | HCID 523102 | — |
| 反応物 | (2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone | HCID 22327293 | — |
| 生成物 | N-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)-phenyl]-4-trifluoromethoxy-benzenesulfonamide | HCID 10254154 | — |
反応手順
The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using (2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone and 4-trifluoromethoxy-benzenesulfonyl chloride and purified by HPLC. 1H NMR (CDCl3) δ 10.17(s, 1H) 8.63 (d, J=4 Hz, 1H) 7.78 (m, 3H) 7.51 (s, 1H) 7.30 (s, 1H) 7.17 (s, 1H) 7.09 (s, 1H) 6.97 (d, J=4 Hz, 2H) 2.64 (s, 3H). MS (ES) m/z=471.0 (M++1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07420055B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-62f889d800ca41bc9c140d0a1f465a24 |
| 出典メモ | uspto-grants-2008_09 |