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Carbon Dioxide → 2-Mercapto-3-isopropylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Dioxide | HCID 280 | — |
| 反応物 | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| 反応物 | Benzenethiol, 2-(1-methylethyl)- | HCID 96003 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 生成物 | 2-Mercapto-3-isopropylbenzoic acid | HCID 10655507 | — |
反応手順
To a solution of 1.0 mmol 2-isopropylthiophenol and 2.2 mmol TMEDA in 2 mL cyclohexane was added 2.2 mmol n-BuLi. Then after stirring 24 h it was added to solid CO2 and stirred for 16 h when extraction and chromatography provided 2-mercapto-3-isopropylbenzoic acid. The methyl ester of this was treated as in example 3 to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731432 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-8bfebd9748154a9780039335f8d6e481 |
| 出典メモ | uspto-grants-1998_03 |