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Benzyl Bromide → 2-Benzylcaprolactone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | epsilon-CAPROLACTONE | HCID 10401 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 生成物 | 2-Benzylcaprolactone | HCID 15188798 | — |
反応手順
A solution of 1 mmol of caprolactone in 0.5 mL THF was added to a solution of LDA in 0.5 mL THF at -78° C. and this stirred for 2 h. Then a solution of 1.1 mmol of a benzylbromide in 0.14 mL DMPU was added to the above mixture and after stirring for 1 h at -15° C., the 2-benzylcaprolactone was isolated by extraction and chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731432 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-1c2ee4b9716b4027b28c9669b15472c1 |
| 出典メモ | uspto-grants-1998_03 |