Ethanol → N-(4-{[(4-aminophenyl)amino]methyl}benzyl)benzene-1,4-diamine tetrahydrochloride

HRID 29732ノート

反応式

HRID 29732 の反応式
[Cl-:1].[NH4+].O.C(O)C.[N+:7]([C:10]1[CH:34]=[CH:33][C:13]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)([O-])=O>CN1C(=O)CCC1.[Zn]>[ClH:1].[ClH:1].[ClH:1].[ClH:1].[NH2:30][C:27]1[CH:26]=[CH:25][C:24]([NH:23][CH2:22][C:19]2[CH:20]=[CH:21][C:16]([CH2:15][NH:14][C:13]3[CH:33]=[CH:34][C:10]([NH2:7])=[CH:11][CH:12]=3)=[CH:17][CH:18]=2)=[CH:29][CH:28]=1

参加物

7

反応物 4

HCID 702EthanolHCID 962WaterHCID 25517Ammonium ChlorideHCID 236567624-nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline

生成物 1

HCID 69252903N-(4-{[(4-aminophenyl)amino]methyl}benzyl)benzene-1,4-diamine tetrahydrochloride

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

The mixture of powdered zinc (22.2 g), ammonium chloride (2.5 g), water (4 ml) and absolute ethanol (20 ml) were brought to reflux with the oil bath. The 4-nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline (3.4 g) was dissolved in 20 ml of NMP and introduced dropwise until there was decoloration of the reaction medium, while at the same time the reflux was maintained.

後処理

  1. temperatureto reflux with the oil bath
  2. additionintroduced dropwise until there
  3. temperaturewhile at the same time the reflux was maintained

出典と根拠

ORDレコード
ord-210702c204ef409592efd42d6c840278
出典データセット
uspto-grants-2008_09
特許番号
US07422609B2

反応ノート

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