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Tetrahydrofuran → 6-Bromohexyl cinnamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| 反応物 | 6-Bromo-1-hexanol | HCID 77970 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 6-Bromohexyl cinnamate | HCID 68849628 | 53% |
反応手順
7 g of 6-bromohexanol was dissolved in a mixed solution of 5 ml of triethylamine as base and 50 ml of THF, and then, cinnamoyl chloride was added dropwise thereto at 0° C. The resultant was filtered to remove the solvent and the residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5) to obtain 8 g of 6-bromohexyl cinnamate (yield: 53%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07422778B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-6c427d124c894c5b946a8d05df74ed6e |
| 出典メモ | uspto-grants-2008_09 |