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Triphenylphosphine → 5-(3-Bromo-4-methylphenyl)-2H-tetrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Azidotrimethylsilane | HCID 78378 | — |
| 反応物 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 反応物 | n-(3-Cyanopropyl)-(3'-bromo-4'-methylphenyl)carboxamide | HCID 19688418 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-(3-Bromo-4-methylphenyl)-2H-tetrazole | HCID 178418249 | — |
反応手順
A solution of 1.0 mmol of this amide, 4.0 mmol of TMSN3, 4.0 mmol of PPh3, and 4.0 mmol of DEAD in 4 mL of THF at 0° C. was stirred 24 h and then concentrated. The residue was mixed with 5 mL of THF and 12.0 mmol of 1N NaOH. After stirring for 24 h and processing by extraction, 5-(3'-bromo-4'-methylphenyl)tetrazole was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731432 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-eddefb32d5b447c197ab4f1fb15647c7 |
| 出典メモ | uspto-grants-1998_03 |