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5-Methyl-3-(4-trifluoromethylphenyl)-1H-[1,2,4]triazole → Tert-butyl {1,1-dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propyl}-carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methyl-3-(4-trifluoromethylphenyl)-1H-[1,2,4]triazole | HCID 23228261 | — |
| 反応物 | tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate | HCID 57429079 | — |
| 生成物 | Tert-butyl {1,1-dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propyl}-carbamate | HCID 86607261 | — |
反応手順
The target compound is obtained analogously to the method described for intermediate product 1c) from 4.90 g (21.6 mmol) 5-methyl-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazol and 7.17 g (32.4 mmol) tert-butyl (3-chloro-1,1-dimethyl-propyl)-carbamate. White solid. Yield: 5.06 g (57%); mass spectroscopy [M+H]+=413.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423036B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-f16bcecf67304ff280fcc11eb5d1c7d1 |
| 出典メモ | uspto-grants-2008_09 |